Hess KC, Jones BH, Marquez B, Chen Y, Ord TS, Kamenetsky M, Miyamoto C, Zippin JH, Kopf GS, Suarez SS et al. (2005) The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.ġ6. Gao X, Sadana R, Dessauer CW, Patel TB. (2007) Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.ġ5. Gao BN, Gilman AG. (1991) Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD. (2004) Raf kinase activation of adenylyl cyclases: isoform-selective regulation.ġ3. Adenylyl cyclase type III is inhibited by Gbetagamma.ġ2. Diel S, Klass K, Wittig B, Kleuss C. (2006) Gbetagamma activation site in adenylyl cyclase type II. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.ġ1. Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R. (2017) International Union of Basic and Clinical Pharmacology. ![]() Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ. (2013) Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.ġ0. Choi EJ, Xia Z, Storm DR. (1992) Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin.ĩ. Chen Y, Harry A, Li J, Smit MJ, Bai X, Magnusson R, Pieroni JP, Weng G, Iyengar R. (1997) Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation. Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, Buck J. (2000) Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.ħ. Chen J, Iyengar R. (1993) Inhibition of cloned adenylyl cyclases by mutant-activated Gi-alpha and specific suppression of type 2 adenylyl cyclase inhibition by phorbol ester treatment.Ħ. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.ĥ. Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J. (1994) Type VIII adenylyl cyclase. Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ. (2017) Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.Ĥ. Brand CS, Hocker HJ, Gorfe AA, Cavasotto CN, Dessauer CW. (2013) Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds.ģ. Beeler JA, Yan SZ, Bykov S, Murza A, Asher S, Tang WJ. (2004) A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase.Ģ. Wu L, Shen C, Seed Ahmed M, Östenson CG, Gu HF. (2016) Adenylate cyclase 3: a new target for anti-obesity drug development.ġ. Wiggins SV, Steegborn C, Levin LR, Buck J. (2018) Pharmacological modulation of the CO 2/HCO 3 -/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase. Johnstone TB, Agarwal SR, Harvey RD, Ostrom RS. (2018) cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes. Halls ML, Cooper DM. (2017) Adenylyl cyclase signalling complexes - Pharmacological challenges and opportunities. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. ![]() * Key recommended reading is highlighted with an asteriskĪntoni FA. (2020) The chilling of adenylyl cyclase 9 and its translational potential.ĭessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R. (2017) International Union of Basic and Clinical Pharmacology. A soluble adenylyl cyclase (AC10) lacks membrane spanning regions and is insensitive to G proteins.It functions as a cytoplasmic bicarbonate (pH-insensitive) sensor. Four families of membranous adenylyl cyclase are distinguishable: calmodulin ( CALM2, CALM3, CALM1, P62158)-stimulated (AC1, AC3 and AC8), Ca 2+- and Gβγ-inhibitable (AC5, AC6 and AC9), Gβγ-stimulated and Ca 2+-insensitive (AC2, AC4 and AC7), and forskolin-insensitive (AC9) forms. 2',5'-dideoxyadenosine), acting through the P-site,are inhibitors of adenylyl cyclase activity. Mammalian membrane-delimited adenylyl cyclases ( nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases ) are typically made up of two clusters of six TM domains separating two intracellular, overlapping catalytic domains that are the target for the nonselective activators Gα s (the stimulatory G protein α subunit) and forskolin (except AC9, ). 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate.
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